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NJSM Office Hours:  Monday-Friday 8:30AM - 4:30PM  |  Phone: 973-998-8301

Prolotherapy

 

Prolotherapy started in the 1930s and the term was coined by Dr. Hackett in the 1950s for “proliferate” therapy.  He defined it as “the rehabilitation of an incompetent structure by the generation of new cellular tissue”.  Prolotherapy is when a stimulating substance (usually dextrose/sugar) is injected to stimulate the body’s intrinsic ability to heal an injury that incompletely resolved or a repetitive stress that is beyond self repair.  It is usually focused at the weak “weld” points of tendon or ligament attachments to bone.

How it Works

The Procedure

Healing Process

Benefits

Prolotherapy

 

There is a rich supply of nerves in the connective tissue that offer feedback to determine different types of pain.  The weakest link is typically at the attachment, but can also occur in the zone where the tendon changes to muscle (musculotendinous junction).  When an area is injured, the body reacts with "inflammation" to "clean" out the damaged tissue and bring in the elements for repair.  Anti-inflammatories (Motrin, Aleve, steroids, etc.) interfere with this healing process if used incorrectly. Healing is not complete when the pain resolves. Studies have demonstrated that after 2 weeks there are no inflammatory cells so there is not continued inflammation, but if unresolved a degenerative process (tendinitis v. tendinosis) occurs.  Weak areas cause overload to adjacent and remote regions in the body.

How it's Done

 

Since there is poor blood supply to most of these injured areas, they are at greater risk for impaired healing.  The classical proliferant is dextrose (i.e. sugar).  This substance stimulates healing in at least two ways.  First, it is more concentrated where injected as opposed to the surrounding injured tissue.  This causes water to shift from the inside to outside of the cell; leading to bursting and causing a minor injury.  The cell substances as well as the dextrose itself stimulates the healing cascade of cells to clear the damage and use new substances to re-build the area (macrophages, growth factors, etc.).  Rehabilitation is very important once the healing has begun to prevent recurrence.  If the precipitating cause can be identified and altered, this should also be addressed.

Healing Process

 

Benefits

 


New Jersey Regenerative Institute  |  197 Ridgedale Avenue, Suite 210, Cedar Knolls, New Jersey 07927  |  973-998-8309

Results may vary based on individual’s overall health, lifestyle, severity of the orthopedic condition being treated and responses are not guaranteed. The information on this site is solely for purposes of general patient education, and may not be relied upon as a substitute for professional medical care. Consult your own physician for evaluation and treatment of your specific condition.